Ethanol → 8-Methoxy-8-(trifluoromethyl)-1,3-diazaspiro[4.5]decane-2,4-dione

Participants

Reaction Conditions

Reaction Steps

8.80 g (44.86 mmol) of 4-methoxy-4-(trifluoromethyl)cyclohexanone (Example 11A), 4.40 g (89.72 mmol) of sodium cyanide and 17.24 g (179.44 mmol) of ammonium carbonate were suspended in 102 ml of ethanol and 102 ml of water. The resulting suspension was stirred at 60° C. for 20 hours. The precipitated product was filtered off, washed with water and dried under reduced pressure. This gave 10.05 g (84% of theory) of the title compound as a white powder.

Provenance & Evidence