HuagongsheHuagongshe Chemistry Print Report · For research reference only
DL-threo-Ritalinic acid → HCID 131734963, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | DL-threo-Ritalinic acid | HCID 10922012 | — |
| Reactant | Di-benzoyl-d-tartaric acid | HCID 12362977 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 131734963 | HCID 131734963 | — |
Reaction Steps
US 2011/0130569 discloses a process for the preparation of the d-threo-ritalinic acid. dl-threo-ritalinic acid treated with (+)-dibenzoyl-D-tartaric acid as resolving agent in large volume of solvents mixture of methanol/water to get d-threo-ritalinic acid-dibenzoyl tartaric acid salt. Thus obtained salt treated with 35% hydrochloric acid in mixture of toluene and water, concentrated under vacuum and isolated by treating with acetone. The volume of resolution solvent used herein is quite higher.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278928B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-64de72ed257142bea8b0ee1569ba13f8 |
| Source note | uspto-grants-2016_03 |