3-(4-Aminophenyl)propionic acid → 3-[4-[[4-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]phenyl]methylamino]phenyl]propanoic acid

HRID 922181Notes

Reaction equation

HRID 922181 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])\[CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([CH:11]=O)=[CH:9][CH:8]=1.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:25][CH:24]=1>>[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])\[CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11][NH:22][C:23]2[CH:24]=[CH:25][C:26]([CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[CH:27][CH:28]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 754513-(4-Aminophenyl)propionic acidHCID 871061194-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]benzaldehyde

Product 1

HCID 566399243-[4-[[4-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]phenyl]methylamino]phenyl]propanoic acidYield 5.5%

Procedure

Compound 6 was synthesized from 4-{[(2Z)-2-(methoxyimino)-2-(2-methylphenyl)ethyl]oxy}benzaldehyde and 3-(4-aminophenyl)propanoic acid by following the procedure described in Scheme 3 (0.10 g, yield: 5.5%); purity: 97.84%.

Sources & evidence

ORD record
ord-1f9de7b1724e4fdc91f9a783c71e22c7
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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