HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Bromomethyl)benzophenone → (1R,2R)-2-{4-[(3-Benzoylbenzyl)amino]phenyl}cyclopropane carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Bromomethyl)benzophenone | HCID 89586 | — |
| Reactant | 3-{4-[(3-Benzoylbenzyl)amino]phenyl}propanoic acid | HCID 66685015 | — |
| Reactant | (1R,2R)-2-(4-aminophenyl)cyclopropane-1-carboxylic acid | HCID 68668314 | — |
| Product | (1R,2R)-2-{4-[(3-Benzoylbenzyl)amino]phenyl}cyclopropane carboxylic acid | HCID 89790287 | 39% |
Reaction Steps
It was prepared from (1R,2R)-2-(4-aminophenyl)cyclopropane carboxylic acid (0.7 g, 3.9 mmol) and [3-(bromomethyl)phenyl](phenyl)methanone (0.9 g, 3.2 mmol) by following the procedure described in Scheme 2 for Intermediate 5. (0.5 g, Yield: 39%). MS (ESI, 120 eV): m/z=372.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-6abed33c33e84f2891158cf5d7408438 |
| Source note | uspto-grants-2016_03 |