HuagongsheHuagongshe Chemistry Print Report · For research reference only
rac-methyl (1R,2R)-2-(4-aminophenyl)cyclopropane-1-carboxylate → trans-(1R,2R)-2-[4-[[4-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]phenyl]methylamino]phenyl]cyclopropane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | rac-methyl (1R,2R)-2-(4-aminophenyl)cyclopropane-1-carboxylate | HCID 68667437 | — |
| Reactant | 4-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]benzaldehyde | HCID 87106119 | — |
| Product | trans-(1R,2R)-2-[4-[[4-[(2Z)-2-methoxyimino-2-(2-methylphenyl)ethoxy]phenyl]methylamino]phenyl]cyclopropane-1-carboxylic acid | HCID 56639928 | 28% |
Reaction Steps
Compound 15 was synthesized from methyl (1R,2R)-2-(4-aminophenyl)cyclopropane carboxylate (0.18 g, 0.9 mmol) and 4-{[(2Z)-2-(methoxyimino)-2-(2-methylphenyl)ethyl]oxy}benzaldehyde (0.31 g, 1.1 mmol) by following the procedure described in Scheme 3 (0.12 g, yield: 28%); Purity: 91.26%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-1afc7c4e8ceb4ee7baae3de37df1b9bc |
| Source note | uspto-grants-2016_03 |