Potassium Hydroxide → HCID 56639929, compound

HRID 922206Notes

Reaction equation

[C:1]([CH:3]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25]/[C:26](=[N:33]\[O:34][CH3:35])/[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)[CH2:4][C:5]([O:7]CC)=[O:6])#[N:2].[OH-].[K+:37]>>[C:1]([CH:3]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25]/[C:26](=[N:33]\[O:34][CH3:35])/[C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[CH:20][CH:19]=2)=[CH:14][CH:15]=1)[CH2:4][C:5]([O-:7])=[O:6])#[N:2].[K+:37]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 86695748HCID 86695748, compound

Product 1

HCID 56639929HCID 56639929, compoundYield 78.34%

Procedure

Compound 31 was synthesized from ethyl 3-cyano-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (0.5 g, 1.06 mmol) and potassium hydroxide (0.093 g, 1.66 mmol) by following the procedure described in Scheme 12 (0.4 g, yield: 78.34%); Purity: 99.27%.

Sources & evidence

ORD record: ord-14fdbfd490c6442fb070ebea3c60ec6b
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278915B2

Reaction notes

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