HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-cyano-3-[4-[[4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate | HCID 66685605 | — |
| Reactant | [4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methanol | HCID 89790283 | — |
| Product | 3-cyano-3-[4-[[4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid | HCID 56640072 | 15.46% |
Reaction Steps
Compound 34 was synthesized from (1Z)-1-(4-fluorophenyl)-2-[4-(hydroxymethyl)phenoxy]ethanone O-methyloxime (0.4 g, 1.46 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.3 g, 1.46 mmol) by following the procedure described in scheme 18 (0.06 g, yield: 15.46%); Purity: 95.29%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d2787337840841fabd7184a2ee52830f |
| Source note | uspto-grants-2016_03 |