Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-cyano-3-[4-[[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate	HCID 66685605	—
Reactant	[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methanol	HCID 89790333	—
Product	3-cyano-3-[4-[[4-[(2Z)-2-(3-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid	HCID 56640141	18.73%

Reaction Steps

Compound 35 was synthesized from (1Z)-1-(3-fluorophenyl)-2-[4-(hydroxymethyl)phenoxy]ethanone O-methyloxime (0.5 g, 1.8 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.372 g, 1.8 mmol) by following the procedure described in scheme 18 (0.1 g, yield: 18.73%); Purity: 95.1%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-597c5954f7a5410283cddec211d475b1
Source note	uspto-grants-2016_03