HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Fluoro-4-hydroxy-phenyl)-propionic acid methyl ester → 3-[2-fluoro-4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Fluoro-4-hydroxy-phenyl)-propionic acid methyl ester | HCID 66685759 | — |
| Reactant | [4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methanol | HCID 87106073 | — |
| Product | 3-[2-fluoro-4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]propanoic acid | HCID 56640207 | 71% |
Reaction Steps
Compound 40 was synthesized from (1Z)-2-[4-(hydroxy methyl)phenoxy]-1-(4-methoxyphenyl)ethanone O-methyloxime (0.25 g, 0.84 mmol) and methyl 3-(2-fluoro-4-hydroxyphenyl)propanoate (0.2 g, 0.94 mmol) by following the procedure described in scheme 18 (0.1 g, yield: 71.00%); Purity: 98.10%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-143111eab4a44c87b8400262a182f691 |
| Source note | uspto-grants-2016_03 |