HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-(4-Hydroxy-2-methoxyphenyl)propanoate → 3-[4-[[4-[(2Z)-2-(4-cyanophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]-2-methoxyphenyl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-(4-Hydroxy-2-methoxyphenyl)propanoate | HCID 66685654 | — |
| Reactant | 4-[(Z)-C-[[4-(hydroxymethyl)phenoxy]methyl]-N-methoxycarbonimidoyl]benzonitrile | HCID 89790231 | — |
| Product | 3-[4-[[4-[(2Z)-2-(4-cyanophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]-2-methoxyphenyl]propanoic acid | HCID 56640210 | 71.5% |
Reaction Steps
Compound 43 was synthesized from 4-{(1Z)-2-[4-(hydroxymethyl)-phenoxy]-N-methoxyethanimidoyl}benzonitrile (0.563 g, 1.9 mmol) and methyl 3-(4-hydroxy-2-methoxyphenyl)propanoate (0.4 g, 1.9 mmol) by following the procedure described in scheme 18 (0.27 g, yield: 71.5%); Purity: 94.96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-e50757432d824895b3594e31b352a210 |
| Source note | uspto-grants-2016_03 |