Methyl 3-[2-(cyanomethyl)-4-hydroxyphenyl]propanoate → 3-[2-(cyanomethyl)-4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenyl]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-[2-(cyanomethyl)-4-hydroxyphenyl]propanoate	HCID 66685719	—
Reactant	(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol	HCID 86695770	—
Product	3-[2-(cyanomethyl)-4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenyl]propanoic acid	HCID 56640276	71%

Reaction Steps

Compound 44 was synthesized from (1Z)-2-[4-(hydroxymethyl)-phenoxy]-1-phenylethanone O-methyloxime (0.3 g, 1.28 mmol) and methyl 3-[2-(cyanomethyl)-4-hydroxyphenyl]propanoate (0.348 g, 1.28 mmol) by following the procedure described in scheme 18 (0.1 g, yield: 71.00%); Purity: 92.72%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-d9d8c419944e41cc95bc572f0462e0da
Source note	uspto-grants-2016_03