Sodium hydride → Npc140395

Temperature

0 °C

To a 500 mL RB flask fitted with magnetic stirrer was charged with 160 mL of tetrahydrofuran. To the stirred solvent was added ethyl phosphonoacetate (16.5 g, 73.6 mmol) under argon atmosphere. The reaction mixture was cooled to 0° C. and sodium hydride (2.65 g, 110 mmol) was added portion wise, stirred for 15 minutes at the same temperature. Then 4-methoxybenzaldehyde (5 g, 36.0 mmol) in tetrahydrofuran (30 mL) was added drop wise. The reaction mixture was stirred at 0° C. for 1 h. The reaction mixture was quenched with water at 0° C. by slow addition, stirred for 10 minutes. The layers were separated; ethyl acetate (50 mL) was added to the aqueous layer and extracted the layers. The organic layer was washed with brine solution (50 mL). The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The product was obtained as pale yellow semi-solid (7.4 g, yield: 98.76%). 1H NMR (300 MHz, CDCl3): δ 7.54-7.60 (d, 1H), 7.39-7.42 (d, 2H), 6.82-6.85 (d, 2H), 6.21-6.26 (d, 1H), 4.15-4.22 (q, 2H), 3.76 (s, 3H), 1.24-1.28 (t, 3H).

1. customTo a 500 mL RB flask fitted with magnetic stirrer
2. stirringThe reaction mixture was stirred at 0° C. for 1 h
3. customThe reaction mixture was quenched with water at 0° C. by slow addition
4. stirringstirred for 10 minutes
5. customThe layers were separated
6. additionethyl acetate (50 mL) was added to the aqueous layer
7. extractionextracted the layers
8. washThe organic layer was washed with brine solution (50 mL)
9. dry with materialThe organic layer was dried over anhydrous Na2SO4
10. customthe solvent was removed under reduced pressure

ORD record

ord-24cfd4d817de46bfa0bc9047b6e4b38f

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09278915B2