Ethyl 2-(4-hydroxyphenyl)cyclopropane-1-carboxylate → 2-[4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(4-hydroxyphenyl)cyclopropane-1-carboxylate	HCID 53374426	—
Reactant	[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methanol	HCID 87106073	—
Product	2-[4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]cyclopropane-1-carboxylic acid	HCID 56640278	13.26%

Reaction Steps

Compound 46 was synthesized from (1Z)-2-[4-(hydroxymethyl)phenoxy]-1-(4-methoxyphenyl)ethanone O-methyloxime (0.146 g, 0.48 mmol) and ethyl 2-(4-hydroxyphenyl)cyclopropanecarboxylate (0.1 g, 0.4 mmol) by following the procedure described in scheme 18 (0.01 g, yield: 13.26%); Purity: 92.24%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-923bd0156ec24ce5a0366e0ada7e6ad1
Source note	uspto-grants-2016_03