Sodium Hydroxide → sodium 3-[2-fluoro-4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]propanoate

HRID 922223Notes

Reaction equation

HRID 922223 reaction equation
[OH-].[Na+:2].[F:3][C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19]/[C:20](=[N:29]\[O:30][CH3:31])/[C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[CH2:32][CH2:33][C:34]([OH:36])=[O:35]>>[F:3][C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19]/[C:20](=[N:29]\[O:30][CH3:31])/[C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[CH2:32][CH2:33][C:34]([O-:36])=[O:35].[Na+:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 566402073-[2-fluoro-4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]propanoic acid

Product 1

HCID 56640279sodium 3-[2-fluoro-4-[[4-[(2Z)-2-methoxyimino-2-(4-methoxyphenyl)ethoxy]phenyl]methoxy]phenyl]propanoateYield 79%

Procedure

Compound 47 was synthesized from sodium hydroxide (0.007 g, 0.18 mmol) and 3-{2-fluoro-4-[(4-{[(2Z)-2-(methoxyimino)-2-(4-methoxyphenyl)ethyl]oxy}benzyl)oxy]phenyl}propanoic acid (0.087 g, 0.18 mmol) by following the procedure described in scheme 12 (0.07 g, yield: 79.00%); Purity: 99.79%.

Sources & evidence

ORD record
ord-fba02ae80730403b9c4f637ebf9ba482
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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