Sodium Hydroxide → sodium 3-cyano-3-[4-[[4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoate

HRID 922226Notes

Reaction equation

HRID 922226 reaction equation
[OH-].[Na+:2].[C:3]([CH:5]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25]/[C:26](/[C:30]3[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=3)=[N:27]\[O:28][CH3:29])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)[CH2:6][C:7]([OH:9])=[O:8])#[N:4]>>[C:3]([CH:5]([C:10]1[CH:11]=[CH:12][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25]/[C:26](/[C:30]3[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=3)=[N:27]\[O:28][CH3:29])=[CH:20][CH:19]=2)=[CH:14][CH:15]=1)[CH2:6][C:7]([O-:9])=[O:8])#[N:4].[Na+:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 566400723-cyano-3-[4-[[4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid

Product 1

HCID 89790220sodium 3-cyano-3-[4-[[4-[(2Z)-2-(4-fluorophenyl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoateYield 73.84%

Procedure

Compound 54 was synthesized from sodium hydroxide (0.067 g, 1.6 mmol) and 3-cyano-3-{4-[(4-{[(2Z)-2-(4-fluorophenyl)-2-(methoxyimino)ethyl]oxy}benzyl)oxy]phenyl}propanoic acid (0.4 g, 0.8 mmol) by following the procedure described in scheme 12 (0.3 g, yield: 73.84%); Purity: 96.50%.

Sources & evidence

ORD record
ord-bc209ab7438c4bfaab7df24f1a24ce68
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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