Sodium Hydroxide → HCID 89790611, compound

HRID 922228Notes

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17]/[C:18](=[N:25]\[O:26][CH3:27])/[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:12]([O:28][CH3:29])[CH:11]=2)[CH:5]=[CH:4][C:3]=1[CH2:30][CH2:31][C:32]([OH:34])=[O:33].[OH-].[Na+:36]>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17]/[C:18](=[N:25]\[O:26][CH3:27])/[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:12]([O:28][CH3:29])[CH:11]=2)[CH:5]=[CH:4][C:3]=1[CH2:30][CH2:31][C:32]([O-:34])=[O:33].[Na+:36]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 56640208HCID 56640208, compound

Product 1

HCID 89790611HCID 89790611, compoundYield 30%

Procedure

Compound 56 was synthesized from 3-{2-fluoro-4-[(3-methoxy-4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid (0.3 g, 0.6 mmol) and sodium hydroxide (0.072 g, 1.8 mmol) by following the procedure described in scheme 12 (0.085 g, yield: 30.00%); Purity: 90.03%.

Sources & evidence

ORD record: ord-7797fc0dedb84f888d56a63d6c0afc84
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278915B2

Reaction notes

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