Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 922230Generated: November 1, 2026

Methyl 3-[2-(cyclopropylmethoxy)-4-hydroxyphenyl]propanoate → 3-[2-(cyclopropylmethoxy)-4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenyl]propanoic acid

https://huagongshe.com/reaction/922230

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-[2-(cyclopropylmethoxy)-4-hydroxyphenyl]propanoateHCID 66686064—
Reactant(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanolHCID 86695770—
Product3-[2-(cyclopropylmethoxy)-4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenyl]propanoic acidHCID 871060064.2%

Reaction Steps

Compound 58 was synthesized from (1Z)-2-[4-(hydroxymethyl)phenoxy]-1-phenylethanone O-methyloxime (0.656 g, 2.4 mmol) and methyl 3-[2-(cyclopropylmethoxy)-4-hydroxyphenyl]propanoate (0.6 g, 2.4 mmol) by following the procedure described in scheme 18 (0.04 g, yield: 4.20%); Purity: 98.15%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09278915B2
Source datasetuspto-grants-2016_03
ORD IDord-5dc8592fce6f48598c1313af372ed977
Source noteuspto-grants-2016_03