Ethyl 3-(4-hydroxy-2 isopropoxyphenyl)propanoate → 3-[4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]-2-propan-2-yloxyphenyl]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 3-(4-hydroxy-2 isopropoxyphenyl)propanoate	HCID 58566451	—
Reactant	(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol	HCID 86695770	—
Product	3-[4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]-2-propan-2-yloxyphenyl]propanoic acid	HCID 87106889	13.73%

Reaction Steps

Compound 60 was synthesized from (1Z)-2-[4-(hydroxymethyl)phenoxy]-1-phenylethanone O-methyloxime (0.268 g, 0.99 mmol) and ethyl 3-(4-hydroxy-2-isopropoxyphenyl)propanoate (0.25 g, 0.99 mmol) by following the procedure described in scheme 15 (0.04 g, yield: 13.73%); Purity: 97.21%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-d0e7e7cb0a094c9da80cf413ff6f71be
Source note	uspto-grants-2016_03