Resorcinol → 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

Participants

Reaction Steps

To a 250 mL RB flask fitted with magnetic stirrer was charged with Ethyl 4-chloroacetoacetate (22.12 g, 134.9 mmol) was dissolved in concentrated sulfuric acid (48 mL) at 0° C., and resorcinol (14.0 g, 127.3 mmol) was added portionwise. The mixture was stirred at room temperature for 2 h. The reaction mixture was poured into ice-water, and the resulting solid was collected by filtration, washed with water, and dried to give 4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (21.0 g, 75.6%) as a beige solid.

Provenance & Evidence