反应详情

The obtained crystals of (6-Hydroxy-1-benzofuran-3-yl)acetic acid suspended in methanol (100 mL), and to the suspension was added concentrated H2SO4 (10 mL), and the mixture was stirred at reflux for 4 h. After evaporation of the solvent, the residue was diluted with ether and subsequently washed with water, saturated sodium hydrogen carbonate solution, and brine, dried over anhydrous sodium sulphate and concentrated to give methyl (6-hydroxy-1-benzofuran-3-yl)acetate. The crude material has been purified by column chromatography to obtain the solid (11.23 g, 58%).

1. temperatureat reflux for 4 h
2. customAfter evaporation of the solvent
3. additionthe residue was diluted with ether
4. washsubsequently washed with water, saturated sodium hydrogen carbonate solution, and brine
5. dry with materialdried over anhydrous sodium sulphate
6. concentrationconcentrated