Methyl 2-(6-hydroxy-1-benzofuran-3-yl)acetate → Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate

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Reaction Steps

The obtained Methyl (6-hydroxy-1-benzofuran-3-yl)acetate (6 g, 29.13 mmol) was hydrogenated on 10% Palladium on carbon (1 g in 1 mL of water) in methanol (60 mL) under hydrogen atmosphere (20 psi) about 24 h. The catalyst was removed by filtration and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give a solid (2.9 g, 47.93%).

Provenance & Evidence