HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-Cyano-3-{4-[(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 3-cyano-3-(4-hydroxyphenyl)propanoate | HCID 66685080 | — |
| Reactant | (4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol | HCID 86695770 | — |
| Product | 3-Cyano-3-{4-[(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid | HCID 56639930 | 39.91% |
Reaction Steps
Compound 74 was synthesized from (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (0.04 g, 2.2 mmol) and benzyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.66 g, 2.2 mmol) by following the procedure described in scheme 24 (0.2 g, yield: 39.91%); Purity: 98.51%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278915B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-488b31eeafe34009b6b024b86b2cb8d9 |
| Source note | uspto-grants-2016_03 |