反应详情

To the microwave vial was charged with isomer methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (+ve) (0.5 g, 2.4 mmole) & benzyl alcohol (0.5 mL, 4.8 mmol), was added tributyltinoxide (0.03 g, 5% W/W). Temperature was set 90° C. & energy is fixed at 250 W for 30 mins. After completion of the reaction (monitored by TLC), the RM mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine solution, dried over anhydrous Na2SO4 and evaporated to dryness gave the titled compound (0.040 g, yield: 6.0%).

1. customwas set 90° C.
2. customAfter completion of the reaction (monitored by TLC)
3. extractionthe RM mixture was extracted with ethyl acetate
4. washThe organic layer was washed with water and saturated brine solution
5. dry with materialdried over anhydrous Na2SO4
6. customevaporated to dryness