Ethanol → HCID 66685791, compound

Participants

Reaction Steps

To a 10 mL RB flask fitted with magnetic stirrer was charged with 3 mL of tetrahydrofuran. To the stirred solvent were added ethyl 3-[2-(3,5-dimethyl-1,2-oxazol-4-yl)-4-hydroxy phenyl]propanoate (0.10 g, 0.35 mmol), ethanol (3 mL) and sodium hydroxide (0.015 g, 0.0.35 mmol) in water (0.5 mL). The reaction mixture was stirred at room 16 h. After completion of the reaction, the solvent was removed, the sodium salt was washed with diethyl ether (5 mL); the aqueous layer was acidified with 1N HCl to pH 2.0 and extracted with ethyl acetate (5 mL). The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure to obtain the product (0.04 g, yield: 44.4%).

Provenance & Evidence