Methyl 3-(4-hydroxyphenyl)hex-4-ynoate → HCID 56640583, compound

HRID 922266Notes

Reaction equation

HRID 922266 reaction equation
[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=1.O[C:22]1[CH:27]=[CH:26][C:25]([CH:28]([C:34]#[C:35][CH3:36])[CH2:29][C:30]([O:32]C)=[O:31])=[CH:24][CH:23]=1>>[CH3:1][O:2]/[N:3]=[C:4](/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)\[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][O:14][C:22]2[CH:27]=[CH:26][C:25]([CH:28]([C:34]#[C:35][CH3:36])[CH2:29][C:30]([OH:32])=[O:31])=[CH:24][CH:23]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 57835749Methyl 3-(4-hydroxyphenyl)hex-4-ynoateHCID 86695770(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

Product 1

HCID 56640583HCID 56640583, compoundYield 20.59%

Procedure

Compound 85 was synthesized from (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (0.2 g, 0.74 mmol) and methyl 3-(4-hydroxyphenyl)hex-4-ynoate (0.16 g, 0.74 mmol) by following the procedure described in scheme 28 (0.03 g, yield: 20.59%); Purity: 98.37%.

Sources & evidence

ORD record
ord-19924f28a33d4cd08bdfe291d22cbf47
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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