Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-cyano-3-[4-[[4-[(2Z)-2-(1H-inden-2-yl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate	HCID 66685605	—
Reactant	[4-[(2Z)-2-(1H-inden-2-yl)-2-methoxyiminoethoxy]phenyl]methanol	HCID 89790335	—
Product	3-cyano-3-[4-[[4-[(2Z)-2-(1H-inden-2-yl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid	HCID 56639624	20.5%

Reaction Steps

Compound 101 was synthesized from (4-{[(2Z)-2-(1H-inden-2-yl)-2-(methoxyimino)ethyl]oxy}phenyl)methanol (0.079 g, 0.4 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.11 g, 0.4 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 20.5%); Purity: 97.17%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-bbb0f0c78ef44fb5b1a79f0285a2f2ce
Source note	uspto-grants-2016_03