Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → 3-cyano-3-[4-[[4-[(2Z)-2-(2,3-dihydro-1-benzofuran-5-yl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate	HCID 66685605	—
Reactant	[4-[(2Z)-2-(2,3-dihydro-1-benzofuran-5-yl)-2-methoxyiminoethoxy]phenyl]methanol	HCID 89790402	—
Product	3-cyano-3-[4-[[4-[(2Z)-2-(2,3-dihydro-1-benzofuran-5-yl)-2-methoxyiminoethoxy]phenyl]methoxy]phenyl]propanoic acid	HCID 56639625	56.2%

Reaction Steps

Compound 102 was synthesized from ((4-{[(2Z)-2-(2,3-dihydro-1-benzofuran-5-yl)-2-(methoxyimino)ethyl]oxy}phenyl)methanol (0.330 g, 1.0 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.216 g, 1.0 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 56.2%); Purity: 94.55%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09278915B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-47f2dd061f914979be20225fcf54af14
Source note	uspto-grants-2016_03