Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → HCID 56639626, compound

HRID 922290Notes

Reaction equation

HRID 922290 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][C:6](/[C:10](=[N:21]/[O:22][CH3:23])/[CH2:11][O:12][C:13]3[CH:18]=[CH:17][C:16]([CH2:19][OH:20])=[CH:15][CH:14]=3)=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[C:24]([CH:26]([C:32]1[CH:37]=[CH:36][C:35](O)=[CH:34][CH:33]=1)[CH2:27][C:28]([O:30]C)=[O:29])#[N:25]>>[C:24]([CH:26]([C:32]1[CH:37]=[CH:36][C:35]([O:20][CH2:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH2:11]/[C:10](/[C:6]3[CH:5]=[C:4]4[C:9](=[CH:8][CH:7]=3)[CH2:1][CH2:2][CH2:3]4)=[N:21]\[O:22][CH3:23])=[CH:14][CH:15]=2)=[CH:34][CH:33]=1)[CH2:27][C:28]([OH:30])=[O:29])#[N:25]

Participants

3

Reactant 2

HCID 66685605Methyl 3-cyano-3-(4-hydroxyphenyl)propanoateHCID 89790494HCID 89790494, compound

Product 1

HCID 56639626HCID 56639626, compoundYield 38.4%

Procedure

Compound 103 was synthesized from (4-{[(2Z)-2-(2,3-dihydro-1H-inden-5-yl)-2-(methoxyimino)ethyl]oxy}phenyl)methanol (0.25 g, 0.8 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.214 g, 1.04 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 38.4%); Purity: 95.42%.

Sources & evidence

ORD record
ord-3357b445b22443869593083f8aae646b
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

Loading…