Methyl 3-cyano-3-(4-hydroxyphenyl)propanoate → HCID 56639703, compound

HRID 922291Notes

Reaction equation

HRID 922291 reaction equation
[CH:1]1(/[C:4](=[N:15]\[O:16][CH3:17])/[CH2:5][O:6][C:7]2[CH:12]=[CH:11][C:10]([CH2:13][OH:14])=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[C:18]([CH:20]([C:26]1[CH:31]=[CH:30][C:29](O)=[CH:28][CH:27]=1)[CH2:21][C:22]([O:24]C)=[O:23])#[N:19]>>[C:18]([CH:20]([C:26]1[CH:31]=[CH:30][C:29]([O:14][CH2:13][C:10]2[CH:11]=[CH:12][C:7]([O:6][CH2:5]/[C:4](/[CH:1]3[CH2:3][CH2:2]3)=[N:15]/[O:16][CH3:17])=[CH:8][CH:9]=2)=[CH:28][CH:27]=1)[CH2:21][C:22]([OH:24])=[O:23])#[N:19]

Participants

3

Reactant 2

HCID 66685605Methyl 3-cyano-3-(4-hydroxyphenyl)propanoateHCID 86695779HCID 86695779, compound

Product 1

HCID 56639703HCID 56639703, compoundYield 44.24%

Procedure

Compound 104 was synthesized from (4-{[(2E)-2-cyclopropyl-2-(methoxyimino)ethyl]oxy}phenyl)methanol (0.5 g, 2.12 mmol) and methyl 3-cyano-3-(4-hydroxyphenyl)propanoate (0.44 g, 2.12 mmol) by following the procedure described in scheme 5 (0.008 g, yield: 44.24%); Purity: 85.80%.

Sources & evidence

ORD record
ord-d73d56892a8e43c5b6f7b9ccf7ad7dc3
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

Loading…