HCID 57835819, compound → HCID 56639772, compound

HRID 922298Notes

Reaction equation

HRID 922298 reaction equation
O[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9][C:10]([O:12]CC)=[O:11])=[CH:4][CH:3]=1.[CH3:21][O:22]/[N:23]=[C:24](/[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)\[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][OH:34])=[CH:29][CH:28]=1>>[CH3:21][O:22]/[N:23]=[C:24](/[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)\[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33][O:34][C:18]2[CH:17]=[CH:16][C:15]([CH:8]([C:5]3[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=3)[CH2:9][C:10]([OH:12])=[O:11])=[CH:20][CH:19]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 57835819HCID 57835819, compoundHCID 86695770(4-{[(2E)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol

Product 1

HCID 56639772HCID 56639772, compoundYield 18.2%

Procedure

Compound 112 was synthesized from ethyl 3-(4-hydroxyphenyl)-3-phenylpropanoate (0.6 g, 2.2 mmol) and (4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}phenyl)methanol (0.6 g, 2.2 mmol) by following the procedure described in scheme 36. (0.2 g, yield: 18.2%); purity: 98.55%.

Sources & evidence

ORD record
ord-b9b8e8e99ea349f7afdd18023c7da6c0
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

Loading…