Tetrahydrofuran → HCID 87106287, compound

Participants

Reaction Steps

To a stirring solution of ethyl 3-{6-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]pyridin-3-yl}propanoate (0.03 g, 0.067 mmol) in the mixture of THF and Ethanol was added aqueous NaOH (0.03 g, 0.067 mmol) at 0° C., then stirred at RT for 2 h. After the completion of the SM reaction mass was concentrated under vacuum at 25° C. to remove solvents and diluted with water. Aqueous portion was neutralized with citric acid up to neutral pH, then extracted with ethyl acetate organic layer was washed with water and brine, dried over Na2SO4 and concentrated. Crude product was purified by preparative TLC to afford colourless oil as product (0.01 g, Yield: 35%); purity: 85%.

Provenance & Evidence