HCID 15685998, compound → HCID 87106532, compound

HRID 922308Notes

Reaction equation

HRID 922308 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Br[CH2:22]/[C:23](/[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[N:24]\[O:25][CH3:26]>>[CH3:26][O:25]/[N:24]=[C:23](/[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)\[CH2:22][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 15685998HCID 15685998, compoundHCID 57015737HCID 57015737, compound

Product 1

HCID 87106532HCID 87106532, compound

Procedure

Compound 115 was synthesized from ethyl 3-(4′-hydroxybiphenyl-4-yl)propanoate (0.27 g, 1 mmol) and (1Z)-2-bromo-N-methoxy-1-phenylethanimine (0.23 g, 1 mmol) by following the procedure described in scheme 39. (0.2 g, 49.8%) purity: 99.5%.

Sources & evidence

ORD record
ord-0067d4f8cd794e7a9d9ca14e306da5f2
Source dataset
uspto-grants-2016_03
Patent number
US09278915B2

Reaction notes

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