4-Hydroxybenzaldehyde → Benzaldehyde, 4-(phenylmethoxy)-

Participants

Reaction Conditions

Reaction Steps

To a 100 mL RB flask fitted with magnetic stirrer was charged 80 mL of acetonitrile. To the stirred solvent was added 4-hydroxy benzaldehyde (4 g, 33 mmol) and K2CO3 (9 g, 65 mmol). Then it was stirred for 5 min. Benzyl bromide (6.7 g, 39 mmol) was added. Then RM heated 80° C. for 2 h. After completion of the reaction (reaction monitored by TLC), the RM was concentrated in vacuum to remove the acetonitrile. To the residue was then added 100 mL of water and extracted with ethyl acetate (150 mL×2). The organic layer was washed with saturated brine solution (50 mL), dried over anhydrous Na2SO4 and evaporated to dryness gave the titled compound (4.5 g, 64.75%).

Provenance & Evidence