Ethanol → 2-[4-[[4-[(2Z)-2-methoxyimino-2-phenylethoxy]phenyl]methoxy]phenoxy]acetic acid

Participants

Reaction Steps

To a 25 mL RB flask fitted with magnetic stirrer was charged 3 mL of ethanol and 3 mL of THF. To the stirred solvent was added ethyl {4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenoxy}acetate (0.13 g, 1.289 mmol) and NaOH was added followed by water (1 mL) at 0° C. Then it was stirred at RT for 5 h. After completion of the reaction (reaction monitored by TLC), reaction mixture was evaporated completely and the crude was washed with ether, and diluted with water and then neutralized with 1N HCl, then extracted with ethyl acetate, organic layer was washed with water and brine, dried over sodium sulphate. The organic layer was evaporated on rotavapor to give the product (0.06 g Yield: 49.5%). Purity: 97.98%

Provenance & Evidence