反应详情

To a 25 mL RB flask fitted with magnetic stirrer was charged 2 mL of Methanol and 2 mL of THF. To the stirred solvent was added methyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate (0.04 g, 0.08 mmol) and NaOH was added followed by water (0.5 mL). Then it was stirred at RT for 12 h, after completion of the reaction (reaction monitored by TLC), reaction mixture was evaporated completely and the crude was washed with ether, and diluted with water and then neutralized with 1N HCl, then extracted with ethyl acetate, organic layer was washed with water and brine, dried over Na2SO4. The organic layer was evaporated on rotavapor under reduced pressure to give the product as a white colour solid. (0.02 g, yield: 52.6%); Purity: 45.3% and 43.6%.

1. customTo a 25 mL RB flask fitted with magnetic stirrer
2. additionwas added
3. customafter completion of the reaction (reaction monitored by TLC), reaction mixture
4. customwas evaporated completely
5. washthe crude was washed with ether
6. additiondiluted with water
7. extractionextracted with ethyl acetate, organic layer
8. washwas washed with water and brine
9. dry with materialdried over Na2SO4
10. customThe organic layer was evaporated on rotavapor under reduced pressure
11. customto give the product as a white colour solid