1-Isopropylpiperazine → HCID 136248828, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(3-bromo-phenyl)-5,7-dimethoxy-3H-quinazolin-4-one (0.5 g, 1.38 mmol), 1-isopropyl-piperazine (0.24 mL, 1.66 mmol), potassium t-butoxide (0.32 g, 3.31 mmol), 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (60.1 mg, 0.096 mmol) and tris(dibenzylideneacetone)dipalladium(0) (31.6 mg, 0.034 mmol) in nitrogen saturated toluene (10 mL) was heated at 100° C. for 48 h. After that time the reaction was cooled to rt and concentrated under reduced pressure. The product was purified by flash column chromatography (silica gel, dichloromethane to 97:3 dichloromethane/methanol) to give 2-(3-(4-isopropylpiperazin-1-yl)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one (0.080 g, 14%) as a yellow solid: mp 251-253° C.; 1H NMR (400 MHz, CDCl3): δ 7.56 (s, 1H), 7.42-7.38 (m, 2H), 7.13-7.09 (m, 1H), 6.84 (d, J=2.4 Hz, 1H), 6.46 (d, J=2.4 Hz, 1H), 3.98 (s, 3H), 3.94 (s, 3H), 3.38-3.28 (m, 4H), 2.78-2.68 (m, 4H), 1.11 (d, 6H); ESI MS m/z 407 (M−1)−

Provenance & Evidence