Cyclopropylamine → HCID 89939681, compound

HRID 922422Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:24][CH3:25])=[C:8]([C:10]#[C:11][CH2:12][NH:13][C:14](=[O:23])[O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:9]=1)(=O)[CH3:2].[CH:26]1([NH2:29])[CH2:28][CH2:27]1>>[CH:26]1([NH:29][CH:1]([C:4]2[CH:5]=[CH:6][C:7]([O:24][CH3:25])=[C:8]([C:10]#[C:11][CH2:12][NH:13][C:14](=[O:23])[O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:9]=2)[CH3:2])[CH2:28][CH2:27]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 89939680HCID 89939680, compound

Product 1

HCID 89939681HCID 89939681, compound

Procedure

Benzyl [3-(5-acetyl-2-methoxyphenyl)prop-2-yn-1-yl]carbamate and cyclopropylamine were treated in the similar manner to Reference Example 6(6) to give benzyl (3-{5-[1-(cyclopropylamino)ethyl]-2-methoxyphenyl}prop-2-yn-1-yl)carbamate [Ex(295-2)] as a yellow oil.

Sources & evidence

ORD record: ord-1b169f4f062340d1a7e992039d30da7b
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278944B2

Reaction notes

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