(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid → HCID 89939678, compound

HRID 922423Notes

Reaction equation

HRID 922423 reaction equation
[CH:1]1([NH:4][CH:5]([C:7]2[CH:8]=[CH:9][C:10]([O:27][CH3:28])=[C:11]([C:13]#[C:14][CH2:15][NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:12]=2)[CH3:6])[CH2:3][CH2:2]1.[C:29]([O:33][C:34]([N:36]1[CH2:41][CH2:40][O:39][C@@H:38]([C:42](O)=[O:43])[CH2:37]1)=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[CH2:19]([O:18][C:17]([NH:16][CH2:15][C:14]#[C:13][C:11]1[CH:12]=[C:7]([CH:5]([N:4]([CH:1]2[CH2:2][CH2:3]2)[C:42]([C@@H:38]2[O:39][CH2:40][CH2:41][N:36]([C:34]([O:33][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:35])[CH2:37]2)=[O:43])[CH3:6])[CH:8]=[CH:9][C:10]=1[O:27][CH3:28])=[O:26])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 6559076(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acidHCID 89939681HCID 89939681, compound

Product 1

HCID 89939678HCID 89939678, compound

Procedure

Benzyl (3-{5-[1-(cyclopropylamino)ethyl]-2-methoxyphenyl}prop-2-yn-1-yl)carbamate and (2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid were treated in the similar manner to Example 162 to give tert butyl (2R)-2-{[{1-[3-(3-{[(benzyloxy)carbonyl]amino}prop-1-yn-1-yl)-4-methoxyphenyl]ethyl}(cyclopropyl)amino]carbonyl}morpholine-4-carboxylate [Ex(295-3)] as a colorless solid.

Sources & evidence

ORD record
ord-5c0fa60633774366b3196c19f4298283
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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