HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanamine, N-methoxy-, hydrochloride (1:1) → 1-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 5-Bromo-6-methoxy-3-pyridinecarboxylic acid | HCID 45790466 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Product | 1-(5-Bromo-6-methoxypyridin-3-yl)ethan-1-one | HCID 83894027 | — |
Reaction Steps
5-Bromo-6-methoxynicotinic acid and N,O-dimethylhydroxylamine hydrochloride were treated in the similar manner to Reference Example 7(5), and then the resulting compound and methylmagnesium bromide were treated in the similar manner to Reference Example 7(6) to give 1-(5-bromo-6-methoxypyridin-3-yl)ethanone [Ex(296-1)] as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278944B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-df787c6a77c74c04923310bf2b837528 |
| Source note | uspto-grants-2016_03 |