Cyclopropylamine → N-(1-(2,6-dichloropyridin-4-yl)ethyl)cyclopropanamine

HRID 922430Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([C:8](=O)[CH3:9])[CH:5]=[C:4]([Cl:11])[N:3]=1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]([NH:15][CH:12]2[CH2:14][CH2:13]2)[CH3:9])[CH:5]=[C:4]([Cl:11])[N:3]=1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 221194461-(2,6-Dichloropyridin-4-YL)ethanone

Product 1

HCID 88931438N-(1-(2,6-dichloropyridin-4-yl)ethyl)cyclopropanamine

Procedure

1-(2,6-Dichloropyridin-4-yl)ethanone and cyclopropylamine were treated in the similar manner to Reference Example 6(6) to give N-[1-(2,6-dichloropyridin-4-yl)ethyl]-cyclopropylamine [Ex(297-1)] as a pale yellow oil.

Sources & evidence

ORD record: ord-30069f04ee5d4621a5ed4b08ad0fe93f
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278944B2

Reaction notes

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