Cyclopropylamine → HCID 89939683, compound

HRID 922432Notes

Reaction equation

[C:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6](/[CH:12]=[CH:13]/[CH2:14][NH:15][C:16](=[O:19])[O:17][CH3:18])[CH:5]=1)(=O)[CH3:2].[CH:20]1([NH2:23])[CH2:22][CH2:21]1>>[CH:20]1([NH:23][CH:1]([C:4]2[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6](/[CH:12]=[CH:13]/[CH2:14][NH:15][C:16](=[O:19])[O:17][CH3:18])[CH:5]=2)[CH3:2])[CH2:22][CH2:21]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 89939682HCID 89939682, compound

Product 1

HCID 89939683HCID 89939683, compound

Procedure

Methyl [(2E)-3-(4-acetyl-6-methoxypyridin-2-yl)prop-2-en-1-yl]carbamate and cyclopropylamine were treated in the similar manner to Reference Example 6(6) to give methyl ((2E)-3-{4-[1-(cyclopropylamino)ethyl]-6-methoxypyridin-2-yl}prop-2-en-1-yl)carbamate [Ex(298-2)] as a colorless oil.

Sources & evidence

ORD record: ord-aa54429bec8d47e98030caf59e87e308
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09278944B2

Reaction notes

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