(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acid → HCID 89939686, compound

HRID 922433Notes

Reaction equation

HRID 922433 reaction equation
[CH:1]1([NH:4][CH:5]([C:7]2[CH:12]=[C:11]([O:13][CH3:14])[N:10]=[C:9](/[CH:15]=[CH:16]/[CH2:17][NH:18][C:19](=[O:22])[O:20][CH3:21])[CH:8]=2)[CH3:6])[CH2:3][CH2:2]1.[C:23]([O:27][C:28]([N:30]1[CH2:35][CH2:34][O:33][C@@H:32]([C:36](O)=[O:37])[CH2:31]1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[CH:1]1([N:4]([CH:5]([C:7]2[CH:8]=[C:9](/[CH:15]=[CH:16]/[CH2:17][NH:18][C:19]([O:20][CH3:21])=[O:22])[N:10]=[C:11]([O:13][CH3:14])[CH:12]=2)[CH3:6])[C:36]([C@@H:32]2[O:33][CH2:34][CH2:35][N:30]([C:28]([O:27][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:29])[CH2:31]2)=[O:37])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6559076(2R)-4-((tert-butoxy)carbonyl)morpholine-2-carboxylic acidHCID 89939683HCID 89939683, compound

Product 1

HCID 89939686HCID 89939686, compound

Procedure

Methyl ((2E)-3-{4-[1-(cyclopropylamino)ethyl]-6-methoxypyridin-2-yl}prop-2-en-1-yl)carbamate and (2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid were treated in the similar manner to Example 162 to give tert-butyl (2R)-2-({cyclopropyl[1-(2-methoxy-6-{(1E)-3-[(methoxycarbonyl)amino]prop-1-en-1-yl}pyridin-4-yl)ethyl]amino}carbonyl)morpholine-4-carboxylate [Ex(298-3)] as a colorless oil.

Sources & evidence

ORD record
ord-fc4676020df14348b93657b7717b8f3c
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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