HCID 88931008, compound → HCID 88931009, compound

HRID 922475Notes

Reaction equation

HRID 922475 reaction equation
[Cl:1][C:2]1[C:7]2[C:8]([CH3:16])=[CH:9][N:10]([CH2:11][CH2:12][CH2:13][O:14][CH3:15])[C:6]=2[CH:5]=[C:4]([C:17](N(OC)C)=[O:18])[N:3]=1.[CH3:23][Mg]Br>>[Cl:1][C:2]1[C:7]2[C:8]([CH3:16])=[CH:9][N:10]([CH2:11][CH2:12][CH2:13][O:14][CH3:15])[C:6]=2[CH:5]=[C:4]([C:17](=[O:18])[CH3:23])[N:3]=1

Participants

3

Reactant 2

HCID 88931008HCID 88931008, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 88931009HCID 88931009, compound

Procedure

4-Chloro-N-methoxy-1-(3-methoxypropyl)-N,3-dimethyl-1H-pyrrolo[3,2-c]pyridine-6-carboxamide and methylmagnesium bromide were treated in the similar manner to Reference Example 6(5) to give 1-[4-chloro-1-(3-methoxypropyl)-3-methyl-1H-pyrrolo[3,2-c]pyridin-6-yl]ethanone [REx(105-8)] as a colorless powder.

Sources & evidence

ORD record
ord-b87ecc2bfe874f5abcd3583e6cb21490
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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