Sodium Hydroxide → HCID 86707870, compound

HRID 922479Notes

Reaction equation

HRID 922479 reaction equation
[CH2:1]([C:3]1[C:7]2[CH:8]=[N:9][C:10]([C:12]([O:14]CC)=O)=[CH:11][C:6]=2[N:5]([CH2:17][CH2:18][CH2:19][O:20][CH3:21])[CH:4]=1)[CH3:2].[OH-].[Na+].Cl.[CH3:25][NH:26][O:27][CH3:28]>>[CH2:1]([C:3]1[C:7]2[CH:8]=[N:9][C:10]([C:12]([N:26]([O:27][CH3:28])[CH3:25])=[O:14])=[CH:11][C:6]=2[N:5]([CH2:17][CH2:18][CH2:19][O:20][CH3:21])[CH:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 89925398HCID 89925398, compound

Product 1

HCID 86707870HCID 86707870, compound

Procedure

Ethyl 3-ethyl-1-(3-methoxypropyl)-1H-pyrrolo[3,2-c]pyridine-6-carboxylate was treated with aqueous sodium hydroxide solution and N,O-dimethylhydroxyamine hydrochloride in the similar manner to Reference Example 105(7) to give 3-ethyl-N-methoxy-1-(3-methoxypropyl)-N-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxamide [REx(106-3)] as a pale yellow oil.

Sources & evidence

ORD record
ord-57ccb6cbce064f588c623e84d30fcd9d
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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