HCID 86707870, compound → HCID 68309722, compound

HRID 922480Notes

Reaction equation

HRID 922480 reaction equation
[CH2:1]([C:3]1[C:7]2[CH:8]=[N:9][C:10]([C:12](N(OC)C)=[O:13])=[CH:11][C:6]=2[N:5]([CH2:18][CH2:19][CH2:20][O:21][CH3:22])[CH:4]=1)[CH3:2].[CH3:23][Mg]Br>>[CH2:1]([C:3]1[C:7]2[CH:8]=[N:9][C:10]([C:12](=[O:13])[CH3:23])=[CH:11][C:6]=2[N:5]([CH2:18][CH2:19][CH2:20][O:21][CH3:22])[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 86707870HCID 86707870, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 68309722HCID 68309722, compound

Procedure

3-Ethyl-N-methoxy-1-(3-methoxypropyl)-N-methyl-1H-pyrrolo[3,2-c]pyridine-6-carboxamide and methylmagnesium bromide were treated in the similar manner to Reference Example 6(5) to give 1-[3-ethyl-1-(3-methoxypropyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]ethanone [REx(106-4)] as a pale yellow oil

Sources & evidence

ORD record
ord-a04676bfbc334d8b96aa2f8c12fbc34d
Source dataset
uspto-grants-2016_03
Patent number
US09278944B2

Reaction notes

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