HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanamine, N-methoxy-, hydrochloride (1:1) → 1-(5-Bromo-6-chloropyridin-3-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-carboxylic acid | HCID 285433 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Product | 1-(5-Bromo-6-chloropyridin-3-yl)ethan-1-one | HCID 20071992 | — |
Reaction Steps
5-Bromo-6-chloronicotinic acid and N,O-dimethylhydroxyamine hydrochloride were treated in the similar manner to Reference Example 7(5), and then the resulting compound and methylmagnesium bromide were treated in the similar manner to Reference Example 7(6) to give 1-(5-bromo-6-chloropyridin-3-yl)ethanone [REx(113-1)] as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09278944B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-6ad8c5688d854ba987658d9b20f74b52 |
| Source note | uspto-grants-2016_03 |