Hydrogen chloride-ethyl acetate → N-[4-(trans-2-aminocyclopropyl)phenyl]benzamide hydrochloride

HRID 922492Notes

Reaction equation

HRID 922492 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])=[CH:13][CH:12]=1)(C)(C)C.[ClH:27].C(OCC)(=O)C>>[ClH:27].[NH2:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:19])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131734967Tert-butyl (trans-2-{4-[(phenylcarbonyl)amino]phenyl}cyclopropyl)carbamate

Product 1

HCID 46236752N-[4-(trans-2-aminocyclopropyl)phenyl]benzamide hydrochloride

Procedure

tert-Butyl(trans-2-{4-[(phenylcarbonyl)amino]phenyl}cyclopropyl)carbamate (212 mg) was dissolved in 4N hydrochloric acid/ethyl acetate solution (2 mL), and the mixture was stirred at room temperature for 2 hr and the solvent was evaporated under reduced pressure to give the title compound (148 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-e3704e3355d847a2877278e42e53fbb8
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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