Hydrogen chloride-ethyl acetate → N-[4-(trans-2-aminocyclopropyl)phenyl]-3-benzylbenzamide hydrochloride

HRID 922508Notes

Reaction equation

HRID 922508 reaction equation
[CH2:1]([C:8]1[CH:9]=[C:10]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C@@H:23]3[CH2:25][C@H:24]3[NH:26]C(=O)OC(C)(C)C)=[CH:19][CH:18]=2)=[O:15])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34].C(OCC)(=O)C>>[ClH:34].[NH2:26][C@@H:24]1[CH2:25][C@H:23]1[C:20]1[CH:19]=[CH:18][C:17]([NH:16][C:14](=[O:15])[C:10]2[CH:11]=[CH:12][CH:13]=[C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:9]=2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729846HCID 86729846, compound

Product 1

HCID 86729847N-[4-(trans-2-aminocyclopropyl)phenyl]-3-benzylbenzamide hydrochloride

Procedure

tert-Butyl [trans-2-(4-{[(3-benzylphenyl)carbonyl]amino}phenyl)cyclopropyl]carbamate (125 mg) was dissolved in 4N hydrochloric acid/ethyl acetate solution (2 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give the title compound (54.7 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6b7f3a81ccc740418939ce985588a584
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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