Hydrogen chloride-ethyl acetate → N-{4-[trans-2-aminocyclopropyl]phenyl}-3-(2-oxopiperidin-1-yl)benzamide hydrochloride

HRID 922519Notes

Reaction equation

HRID 922519 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][C:27]3=[O:32])[CH:21]=2)=[O:19])=[CH:13][CH:12]=1)(C)(C)C.[ClH:34].C(OCC)(=O)C>>[ClH:34].[NH2:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:19])[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N:26]3[CH2:31][CH2:30][CH2:29][CH2:28][C:27]3=[O:32])[CH:21]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131734969Tert-butyl{trans-2-[4-({[3-(2-oxopiperidin-1-yl)phenyl]carbonyl}amino)phenyl]cyclopropyl}-carbamate

Product 1

HCID 86729861N-{4-[trans-2-aminocyclopropyl]phenyl}-3-(2-oxopiperidin-1-yl)benzamide hydrochloride

Procedure

A mixed solution of tert-butyl{trans-2-[4-({[3-(2-oxopiperidin-1-yl)phenyl]carbonyl}amino)phenyl]cyclopropyl}-carbamate (53.4 mg) in 4N hydrochloric acid/ethyl acetate solution (2 mL) was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (38.5 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-8d2260d53c0e4ce2b2ef62d60d478a2a
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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