Hydrogen chloride-ethyl acetate → HCID 86729866, compound

HRID 922522Notes

Reaction equation

HRID 922522 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)=[O:19])=[CH:13][CH:12]=1)(C)(C)C.[ClH:33].C(OCC)(=O)C>>[ClH:33].[NH2:7][C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:12]=[CH:13][C:14]([NH:17][C:18]([C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:22][CH:21]=2)=[O:19])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131734970HCID 131734970, compound

Product 1

HCID 86729866HCID 86729866, compound

Procedure

tert-Butyl(trans-2-{4-[(biphenyl-4-ylcarbonyl)amino]phenyl}cyclopropyl)carbamate (154 mg) was dissolved in 4N hydrochloric acid/ethyl acetate solution (2 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (81.9 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-cdb4927b77e7482daa803804bf3e439a
Source dataset
uspto-grants-2016_03
Patent number
US09278931B2

Reaction notes

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